Charles Bronson plays a man named James Otis, who is disturbed by dreams of a giant white buffalo. He returns to the west under his new name Wild Bill Hickok. Amongst his travels, he meets Chief Crazy Horse [Will Sampson], who is roaming the plains in an obsessive search for the giant white buffalo that killed his young daughter. Chief Crazy Horse wants to slay the beast in revenge for his daughter's death, and Wild Bill Hickok teams up with him to hunt down the giant white buffalo